VEXAS syndrome
The American College of Rheumatology guidance statement on VEXAS syndrome
Published in March 2026, it sets out what an international panel considers established about the diagnosis, treatment and monitoring of a disease first described in 2020 — and what is not.
Research areas
VEXAS syndrome
Acquired adult-onset autoinflammatory disease caused by somatic UBA1 mutation.
Reproductive immunology
Immune tolerance in pregnancy and repeated pregnancy failure.
Recurrent pregnancy loss
When the standard work-up is negative: the internal medicine approach.
Antiphospholipid syndrome
Obstetric and refractory forms; the place of hydroxychloroquine.
Repeated implantation failure
Immune investigations after repeated embryo transfers.
Inflammatory placental lesions
Chronic histiocytic intervillositis, chronic villitis, massive perivillous fibrin deposition.
Pregnancy and autoimmune disease
Preconception planning and treatment adjustment.
Autoinflammatory diseases and AA amyloidosis
Familial Mediterranean fever and related syndromes; CeRéMAIA reference centre.